منابع مشابه
Prostacyclin analogues: the next drug-eluting stent?
Recent concern over existing drug-eluting stents, for the treatment of myocardial ischaemia, has led to the development of approaches that seek to inhibit restenosis while promoting the recovery of a functional endothelium. Prostacyclin analogues may be worthy candidates for use within a drug-eluting stent by virtue of their wide profile of vasoprotective effects. This article reviews recent de...
متن کاملPlatelet actions of stable carbocyclic analogues of prostacyclin.
SINCE THE TIME of the discovery of prostacyclin' and the elucidation of its chemical structure as prostaglandin (PG) (5Z)-9 deoxy-6, 9 a-epoxy-&APGF,,2 many synthetic prostacyclin analogues have been prepared and reported in the literature. Although prostacyclin (epoprostenol) is now available for clinical use as the freeze-dried sodium salt that, when mixed with the diluent buffer (sodium chlo...
متن کاملProstacyclin analogues differentially inhibit growth of distal and proximal human pulmonary artery smooth muscle cells.
BACKGROUND Prostacyclin has proved to be a beneficial treatment for patients with severe pulmonary hypertension. We postulated that the response may reflect, at least in part, inhibition of pulmonary artery smooth muscle cell (PASMC) growth. METHODS AND RESULTS Human PASMCs were derived from distal (<1-mm external diameter, n=8) and proximal (>8-mm external diameter, n=12) pulmonary arteries ...
متن کاملEffects of prostacyclin analogues on human endothelial cell tissue factor expression.
Prostacyclin analogues have been reported to inhibit the expression of tissue factor procoagulant activity in human monocytes, primarily by elevating intracellular levels of adenosine 3',5'-cyclic monophosphate (cAMP). The present studies have investigated whether prostacyclins can also inhibit tissue factor expression in endothelial cells. Iloprost, carbacyclin, and ciprostene had no effect on...
متن کاملPLATELETS AND VASCULAR OCCLUSION Platelet actions of stable carbocyclic analogues of prostacyclin
SINCE THE TIME of the discovery of prostacyclin' and the elucidation of its chemical structure as prostaglandin (PG) (5Z)-9 deoxy-6, 9 a-epoxy-&APGF,,2 many synthetic prostacyclin analogues have been prepared and reported in the literature. Although prostacyclin (epoprostenol) is now available for clinical use as the freeze-dried sodium salt that, when mixed with the diluent buffer (sodium chlo...
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ژورنال
عنوان ژورنال: European Journal of Vascular and Endovascular Surgery
سال: 1996
ISSN: 1078-5884
DOI: 10.1016/s1078-5884(96)80063-3